Why the study?
Do thromboembolic events worsen prognosis in patients with invasive exocrine pancreatic cancer?
Do thromboembolic events worsen prognosis in patients with invasive exocrine pancreatic cancer?
Early thromboembolic events were associated with worse prognosis in exocrine pancreatic cancer; hypothesis-generating for prophylaxis and trial stratification.
TEs are common in exocrine pancreatic cancer, with coagulopathy, erythropoietin-stimulating agent use, and underweight BMI influencing thrombosis timing. TEs, particularly early ones, confer a significantly worse prognosis, suggesting a biological significance, underscoring the relevance of ongoing prophylaxis trials, and raising the question of whether early TEs should be considered a stratification factor for clinical trials.
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Epstein et al. (2011) studied this question.
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