Why the study?
Does suboptimal glycemic control worsen aortic stiffness, left ventricular mass, and diastolic function in patients with type 2 diabetes mellitus?
Does suboptimal glycemic control worsen aortic stiffness, left ventricular mass, and diastolic function in patients with type 2 diabetes mellitus?
Suboptimal glycemic control in T2DM patients is associated with subclinical structural and functional cardiac deterioration, including increased aortic stiffness and worse longitudinal performance.
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Suboptimal glycemic control is associated with subclinical LV and aortic changes in T2DM; hypothesis-generating and requires prospective confirmation before informing practice.
One-third of T2DM patients with preserved LV ejection fraction has sign of subclinical LV diastolic dysfunction. HbA1c levels are positively associated with LV mass and aortic stiffness, both of which show a negative independent impact on early diastolic velocity e', the latter through an increase in afterload. T2DM patients with suboptimal glycemic control (HbA1c ≥ 6.5%) have lower diastolic and systolic LV longitudinal performance, together with increased aortic stiffness and a higher prevalence of LV hypertrophy.
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Kozàkovà et al. (2017) studied this question.
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