November 13, 2001Circulation
Abnormal Epicardial Coronary Resistance in Patients With Diffuse Atherosclerosis but “Normal” Coronary Angiography
Population
Patients with diffuse atherosclerosis but "normal" coronary angiography
Design
Other
Authors
Discussion
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Member takes
Implication
May warrant physiology assessment beyond angiography in diffuse CAD; leaves open whether intervening on continuous gradients improves outcomes.
Key Points
- To investigate the effects of diffuse coronary atherosclerosis on epicardial resistance in patients with normal angiography.
- Assessment of epicardial coronary resistance in patients with diffuse atherosclerosis
- Analysis of pressure changes along arterial length
- Evaluation of flow implications for myocardial ischemia
- Continuous pressure fall observed along arterial length in diffuse atherosclerosis (p<0.01)
- Increased epicardial resistance linked to myocardial ischemia
- Impacts decision-making for percutaneous coronary interventions
Structured PICO
P
Population
Patients with diffuse atherosclerosis but "normal" coronary angiography
Diffuse coronary atherosclerosis without focal stenosis causes resistance to flow that contributes to myocardial ischemia, which has consequences for decision-making during percutaneous coronary interventions.
Cite This Study
Bruyne et al. (2001) studied this question.