July 21, 1998Proceedings of the National Academy of SciencesOpen Access

Potent inhibition of respiratory syncytial virus replication using a 2-5A-antisense chimera targeted to signals within the virus genomic RNA

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Why the study?

Does a 2-5A-antisense chimera (NIH351) inhibit RSV replication in cell culture models compared to ribavirin?

Population

Cell culture models of respiratory syncytial virus (RSV) infection (strains A and B subgroups)

Comparison

2-5A-antisense chimera targeting a consensus… vs Ribavirin, scrambled nucleotide sequence…

Design

Preclinical

Authors

MPMark R. PlayerJohnson & Johnson (United States)DBDale L. BarnardTun Abdul Razak Research Centre PTPaul F. TorrenceCleveland State University

Discussion

Member takes

Implication

May advance 2-5A-antisense chimeras for RSV; leaves open translation beyond cell culture.

Structured PICO

Does a 2-5A-antisense chimera (NIH351) inhibit RSV replication in cell culture models compared to ribavirin?

Population

Cell culture models of respiratory syncytial virus (RSV) infection (strains A and B subgroups)

Intervention

2-5A-antisense chimera (NIH351) targeting a consensus sequence within the RSV genomic RNA

Comparator

Ribavirin, scrambled nucleotide sequence chimera, and a congener with a disabled 2-5A moiety

Outcome

Inhibition of RSV replicationsurrogate

A novel 2-5A-antisense chimera (NIH351) demonstrates highly potent, specific, and targeted inhibition of RSV replication in vitro, significantly outperforming ribavirin.

Cite This Study

Player et al. (1998) studied this question.

synapsesocial.com/papers/69d570e675589c71d767dff0 https://doi.org/10.1073/pnas.95.15.8874

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Potent inhibition of respiratory syncytial virus replication using a 2-5A-antisense chimera targeted to signals within the virus genomic RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potent inhibition of respiratory syncytial virus replication using a 2-5A-antisense chimera targeted to signals within the virus genomic RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider