What question did this study set out to answer?

Review the physiological mechanisms of platelet activation and thrombosis while evaluating established and emerging anti-platelet therapies.

Platelets and Anti-platelet Therapy

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May inform clinician reference on antiplatelet mechanisms; leaves open comparative efficacy of emerging agents.

Review the physiological mechanisms of platelet activation and thrombosis while evaluating established and emerging anti-platelet therapies.
Synthesized mechanistic data on platelet adhesion, aggregation, and catalytic facilitation of thrombin and fibrin formation.
Evaluated clinical evidence for existing anti-thrombotic drug classes and surveyed novel molecular therapeutic targets.
Cyclooxygenase inhibitors blocking thromboxane and thienopyridine derivatives blocking ADP receptors demonstrate therapeutic and prophylactic efficacy in large trials.
Intravenous alpha IIb beta 3 antagonists provide targeted anti-thrombotic benefits, whereas oral formulations show disappointing outcomes in clinical studies.
Emerging potential targets identified from platelet physiology include the thrombin receptor, the serotonin handling system, and the leptin receptor.

McNicol et al. (2003) studied this question.

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