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Design
Preclinical
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Alamandine pathway discovery is hypothesis-generating in animals; human validation required before any therapeutic consideration.
The identification of these 2 novel components of the RAS, alamandine and its receptor, provides new insights for the understanding of the physiological and pathophysiological role of the RAS and may help to develop new therapeutic strategies for treating human cardiovascular diseases and other related disorders.
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Lautner et al. (2013) studied this question.
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