Key result
Alamandine improved aspects of cardiac remodeling induced by pressure overload in mice, including cell hypertrophy, fibrosis, and oxidative stress markers.
Why the study?
Alamandine is a promising target for cardiovascular disease treatment, but its effects on cardiac remodeling induced by pressure overload had not been demonstrated.
Does alamandine improve cardiac remodeling induced by transverse aortic constriction in mice?
Population
Mice with transverse aortic constriction
Authors
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May merit further preclinical study; leaves open translation to human pressure-overload therapies.
Does alamandine improve cardiac remodeling induced by transverse aortic constriction in mice?
Alamandine may be a promising therapeutic target for cardiovascular disease by improving cardiac remodeling induced by pressure overload.
Silva et al. (2020) studied Cardiac remodeling induced by pressure overload. Alamandine was evaluated on Cardiac remodeling (cell hypertrophy, fibrosis, and oxidative stress markers). Alamandine improved aspects of cardiac remodeling induced by pressure overload in mice, including cell hypertrophy, fibrosis, and oxidative stress markers.
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