Key result
Alamandine treatment prevented angiotensin II-induced hypertrophy in cardiomyocytes by inducing AMPK/NO signaling via the MrgD receptor.
Why the study?
Does alamandine prevent angiotensin II-induced hypertrophy in cardiomyocytes?
Population
Cardiomyocytes from C57BL/6 mice (wild-type, Mas-/-, MrgD-/-) and cultured neonatal rat cardiomyocytes (NRCMs)
Comparison
Alamandine treatment vs Untreated cells, or cells treated with MrgD…
Design
Preclinical
Authors
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Hypothesis-generating for alamandine effects in cardiomyocytes; leaves open clinical relevance in cardiovascular disease.
Does alamandine prevent angiotensin II-induced hypertrophy in cardiomyocytes?
Alamandine acts via the MrgD receptor to induce AMPK/NO signaling, providing a protective effect against angiotensin II-induced cardiomyocyte hypertrophy.
Jesus et al. (2018) studied Angiotensin II-induced hypertrophy. Alamandine was evaluated on Nitric oxide (NO) production and prevention of ANG II-induced hypertrophy. Alamandine treatment prevented angiotensin II-induced hypertrophy in cardiomyocytes by inducing AMPK/NO signaling via the MrgD receptor.