Why the study?
Although alamandine shows cardioprotective effects, data on its role in vascular remodelling events remained scarce.
Does alamandine attenuate arterial remodeling and inflammation in mice subjected to transverse aortic constriction?
Population
C57BL/6J male mice
Comparison
TAC plus alamandine vs TAC alone vs sham operation
Design
Controlled animal experimental study
Follow-up
14 days
Authors
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Hypothesis-generating for alamandine in vascular remodeling; leaves open translation to human cardiovascular disease.
Does alamandine attenuate arterial remodeling and inflammation in mice subjected to transverse aortic constriction?
Alamandine demonstrates anti-fibrotic and anti-inflammatory effects that attenuate vascular remodeling in a murine model of transverse aortic constriction, suggesting potential as a therapeutic target for vascular disease.
Souza-Neto et al. (2019) studied this question.
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