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April 6, 2020JAMA Network Open143 citationsOpen Access

Association Between Use of Warfarin for Atrial Fibrillation and Outcomes Among Patients With End-Stage Renal Disease

MRMandeep RandhawaRVRohanlal VishwanathPMP Manoj

Key Points

  • To evaluate the association of warfarin use with outcomes in patients with atrial fibrillation and end-stage renal disease.
  • Review of multiple studies on warfarin use
  • Assessment of stroke incidence and bleeding risks
  • Comparison of outcomes related to mortality
  • Warfarin use showed no change in ischemic stroke incidence
  • Significantly higher risk of hemorrhagic stroke associated with warfarin
  • No significant difference found in major bleeding risk or mortality rates

Abstract

In the studies reviewed, warfarin use appears to have been associated with no change in the incidence of ischemic stroke in patients with atrial fibrillation and end-stage renal disease. However, from the studies reviewed, it does appear to be associated with a significantly higher risk of hemorrhagic stroke, with no significant difference in the risk of major bleeding, and with no change in mortality.

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Cite This Study

Randhawa et al. (2020) studied this question.

synapsesocial.com/papers/69d5719b75589c71d767e38ahttps://doi.org/10.1001/jamanetworkopen.2020.2175
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