Why the study?
Does mild elevation of resting mean pulmonary arterial pressure (20-25 mm Hg) predict poor survival in patients at risk for pulmonary hypertension or with unexplained dyspnea?
Does mild elevation of resting mean pulmonary arterial pressure (20-25 mm Hg) predict poor survival in patients at risk for pulmonary hypertension or with unexplained dyspnea?
Mild elevation of resting mean pulmonary arterial pressure (20-25 mm Hg) is an independent predictor of poor survival in patients at risk for pulmonary hypertension or with unexplained dyspnea.
Mild mPAP elevation may indicate higher mortality risk in at-risk patients; hypothesis-generating and should not yet change PH classification or management.
In patients at risk for PH and/or with unexplained dyspnea, CART analysis detects prognostic thresholds at a resting mPAP of 17 mm Hg and 26 mm Hg, and values between 20 mm Hg and 25 mm Hg represent an independent predictor of poor survival. Clinical trial registered with www.clinicaltrials.gov (NCT 01607502).
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Douschan et al. (2017) studied this question.
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