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November 30, 2016MedicineOpen Access

Cumulative systolic blood pressure exposure in relation to cognitive function in middle-aged and elderly adults

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Why the study?

Does higher cumulative systolic blood pressure exposure worsen cognitive function in middle-aged and elderly adults?

Population

2,211 middle-aged and elderly adults from the Asymptomatic Polyvascular Abnormalities Community study.

Comparison

Higher cumulative systolic blood pressure… vs Lower cumulative systolic blood pressure exposure.

Design

Cohort

Follow-up

From baseline to the fourth examination

Authors

JLJie LiuYHYu‐Ling HuangGCGuojuan Chen

Discussion

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Member takes

Overview

Supports SBP monitoring in middle-aged adults; hypothesis-generating, should not change practice without RCTs.

Structured PICO

Does higher cumulative systolic blood pressure exposure worsen cognitive function in middle-aged and elderly adults?

P
Population
2,211 middle-aged and elderly adults (aged 40-94 years, 41.4% female) from the Asymptomatic Polyvascular Abnormalities Community (APAC) study.
I
Intervention
Higher cumulative systolic blood pressure (SBP) exposure (calculated by consecutive SBP values measured through baseline up to the fourth examination).
C
Comparator
Lower cumulative systolic blood pressure (SBP) exposure.
O
Outcome
Cognitive function estimated by mini-mental state examination (MMSE) in the fourth examination.surrogate

Greater cumulative exposure to systolic blood pressure over time is independently associated with worse cognitive performance, particularly in adults aged 60 years and older.

Cite This Study

Liu et al. (2016) studied this question.

synapsesocial.com/papers/69d5722575589c71d767e532https://doi.org/10.1097/md.0000000000005514
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