The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010

This is the authors' abstract. We don't add key points for this paper.

Drug regimens are increasingly complex and potentially harmful, and people with polypharmacy need regular review and prescribing optimisation. Research is needed to better understand the impact of multiple interacting drugs as used in real-world practice and to evaluate the effect of medicine optimisation interventions on quality of life and mortality.

May prompt polypharmacy review in practice; leaves open optimal optimization strategies for prospective trials.