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May prompt polypharmacy review in practice; leaves open optimal optimization strategies for prospective trials.
Drug regimens are increasingly complex and potentially harmful, and people with polypharmacy need regular review and prescribing optimisation. Research is needed to better understand the impact of multiple interacting drugs as used in real-world practice and to evaluate the effect of medicine optimisation interventions on quality of life and mortality.
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Guthrie et al. (2015) studied this question.
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