Key result
Ventricular myocyte sodium channel subtypes segregate distinctly between intercalated disks and transverse tubules.
Different sodium channel alpha and beta subunits exhibit distinct subcellular localization in mouse ventricular myocytes, which may have implications for understanding cardiac electrophysiology.
Distinct murine myocyte sodium channel localization warrants no clinical practice change; leaves open human translation and functional roles.
Our results suggest that the primary sodium channels present in ventricular myocytes are composed of Na(v)1.5 plus beta2 and/or beta4 subunits in intercalated disks and Na(v)1.1, Na(v)1.3, and Na(v)1.6 plus beta1 and/or beta3 subunits in the transverse tubules.
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Maier et al. (2004) studied this question. Ventricular myocyte sodium channels show distinct localization, with Na(v)1.5 plus beta2/beta4 in intercalated disks and Na(v)1.1, 1.3, and 1.6 plus beta1/beta3 in transverse tubules.
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