Different sodium channel alpha and beta subunits exhibit distinct subcellular localization in mouse ventricular myocytes, which may have implications for understanding cardiac electrophysiology.
Our results suggest that the primary sodium channels present in ventricular myocytes are composed of Na(v)1.5 plus beta2 and/or beta4 subunits in intercalated disks and Na(v)1.1, Na(v)1.3, and Na(v)1.6 plus beta1 and/or beta3 subunits in the transverse tubules.
Maier et al. (Tue,) studied this question.