Why the study?
Does ambulatory blood pressure monitoring provide incremental utility over clinic blood pressure in predicting cardiovascular events in treated hypertensive patients?
Does ambulatory blood pressure monitoring provide incremental utility over clinic blood pressure in predicting cardiovascular events in treated hypertensive patients?
Ambulatory blood pressure monitoring, particularly nocturnal pressures, provides incremental prognostic value over standard clinic blood pressure for predicting cardiovascular events in treated hypertensive patients.
May support nocturnal ABPM for refined risk stratification in treated hypertension; leaves open need for outcome trials.
The amlodipine-perindopril and atenolol-thiazide regimens had different effects on daytime and night-time ABP, which may have contributed to the lower rates of events in patients treated with amlodipine-perindopril therapy. Both CBP and ABP were significantly associated with rates of cardiovascular events. ABP nocturnal pressures provided complimentary and incremental utility over CBP in the prediction of cardiovascular risk in treated hypertensive patients. These data support the use of ABP to assess the effect of antihypertensive treatment in clinical practice.
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Dolan et al. (2009) studied this question.
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