Observational analysis demonstrates an inverse link between cholesterol efflux capacity and coronary artery disease, indicating that HDL quality matters beyond absolute cholesterol levels.
Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima-media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level. (Funded by the National Heart, Lung, and Blood Institute and others.).
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Khera et al. (2011) studied this question.
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