Why the study?
Does pharmacological conversion with bepridil alone or in combination with aprindine improve recovery of atrial mechanical function and maintain sinus rhythm longer than electrical conversion in patients with long-lasting persistent atrial fibrillation?
Does pharmacological conversion with bepridil alone or in combination with aprindine improve recovery of atrial mechanical function and maintain sinus rhythm longer than electrical conversion in patients with long-lasting persistent atrial fibrillation?
Pharmacological conversion with bepridil (with or without aprindine) may offer advantages over electrical conversion for restoring atrial mechanical function and maintaining sinus rhythm in long-lasting persistent AF.
Answers are grounded in this paper and cite their sources.
May support bepridil-based pharmacological conversion in long-lasting persistent AF; leaves open randomized confirmation before practice change.
In patients with long-lasting AF, pharmacological conversion with bepridil alone or in combination with aprindine recovered atrial mechanical function better and maintained sinus rhythm longer than electrical conversion.
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Fujiki et al. (2004) studied this question.
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