Is the concomitant use of clopidogrel and Proton Pump Inhibitors still associated with increased adverse cardiovascular outcomes following coronary angioplasty?: a systematic review and meta-analysis of recently published studies (2012 – 2016)

Fig. 1. Flow diagram for the study selection

Fig. 2. Short term adverse clinical outcomes associated with the concomitant use of clopidogrel and PPIs

Fig. 3. Short term Myocardial Infarction associated with the concomitant use of clopidogrel and PPIs

Fig. 4. Long term adverse clinical outcomes associated with the concomitant use of clopidogrel and PPIs

Fig. 5. Long term mortality and TVR associated with the concomitant use of clopidogrel and PPIs

Fig. 6. a and b Funnel plots showing publication bias