July 1, 2015EuroIntervention
Unravelling the (arte)fact of increased pacemaker rate with the Edwards SAPIEN 3 valve
Why the study?
Does the Edwards SAPIEN 3 valve increase the incidence of permanent pacemaker implantation compared to the XT valve in patients undergoing TAVI?
Population
Patients undergoing transcatheter aortic valve implantation (TAVI)
Comparison
Edwards SAPIEN 3 transcatheter heart valve vs SAPIEN XT transcatheter heart valve (XT-THV)
Design
Cohort
Authors
Discussion
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Member takes
Implication
May warrant higher S3-THV implantation to reduce PPMI risk; hypothesis-generating pending randomized confirmation.
Structured PICO
Does the Edwards SAPIEN 3 valve increase the incidence of permanent pacemaker implantation compared to the XT valve in patients undergoing TAVI?
P
Population
Patients undergoing transcatheter aortic valve implantation (TAVI)
I
Intervention
Edwards SAPIEN 3 transcatheter heart valve (S3-THV)
C
Comparator
SAPIEN XT transcatheter heart valve (XT-THV)
O
Outcome
Incidence of permanent pacemaker implantation (PPMI)safety
Higher pacemaker rates with the SAPIEN 3 valve compared to the XT valve are driven by deep valve implantation, suggesting that a higher implantation technique may prevent this complication without increasing paravalvular leak.
Cite This Study
Tarantini et al. (2015) studied this question.