Why the study?
Does endothelin-1 induce myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy iPSC-derived cardiomyocytes?
Does endothelin-1 induce myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy iPSC-derived cardiomyocytes?
Endothelin-1 interacts with genetic backgrounds to promote pathological phenotypes and contractile variability in in vitro models of hypertrophic cardiomyopathy.
Does not support endothelin-1 targeting in HCM; leaves open clinical translation of iPSC gene-environment findings.
Interactions between the patient's genetic backgrounds and the environmental factor endothelin-1 promote the HCM pathological phenotype and contractile variability in the HCM iPSC-derived cardiomyocytes.
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Tanaka et al. (2014) studied this question.
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