Does endothelin-1 induce myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy iPSC-derived cardiomyocytes?
Endothelin-1 interacts with genetic backgrounds to promote pathological phenotypes and contractile variability in in vitro models of hypertrophic cardiomyopathy.
Interactions between the patient's genetic backgrounds and the environmental factor endothelin-1 promote the HCM pathological phenotype and contractile variability in the HCM iPSC-derived cardiomyocytes.
Tanaka et al. (Wed,) studied this question.