What question did this study set out to answer?

Characterize the biological involvement of elevated TNF-α in mild cognitive impairment and Alzheimer's disease, and evaluate the therapeutic potential of pharmacological TNF-α inhibition.

December 26, 2023CellsOpen Access

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

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Authors

DPDomenico PlantoneUniversity of Siena MPMatteo PardiniAzienda Ospedaliera S.Maria DRDelia RighiUniversity of Siena

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Implication

Narrative review demonstrates reduced dementia risk following TNF-alpha inhibition in inflammatory disease populations, highlighting anti-inflammatory therapy as a potential strategy to preserve...

Key Points

Characterize the biological involvement of elevated TNF-α in mild cognitive impairment and Alzheimer's disease, and evaluate the therapeutic potential of pharmacological TNF-α inhibition.
Synthesized findings from a narrative review encompassing preclinical animal models and human clinical investigations of TNF-α in neurodegenerative conditions.
Evaluated clinical evidence from patients with rheumatoid arthritis and systemic inflammatory diseases treated with pharmacological TNF-α inhibitors.
Patients with rheumatoid arthritis and systemic inflammatory diseases receiving TNF-α blocking agents exhibit a lower probability of developing dementia relative to the general population.
Preclinical and clinical findings demonstrate that neuroinflammatory cascades and subsequent glial activation contribute centrally to Alzheimer's disease progression, supporting TNF-α as a viable therapeutic target.

Cite This Study

Plantone et al. (2023) studied this question.

synapsesocial.com/papers/69d573efcb7e4bf698cf401e https://doi.org/10.3390/cells13010054

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Implication

Narrative review demonstrates reduced dementia risk following TNF-alpha inhibition in inflammatory disease populations, highlighting anti-inflammatory therapy as a potential strategy to preserve...

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

Discussion

Member takes

Implication

Key Points

Cite This Study

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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