Why the study?
Does dysferlin deficiency impair baseline cardiac function and beta-adrenergic-dependent lusitropic response in mouse hearts?
Does dysferlin deficiency impair baseline cardiac function and beta-adrenergic-dependent lusitropic response in mouse hearts?
Dysferlin deficiency causes early diastolic dysfunction and blunts the lusitropic response to beta-adrenergic stimulation, revealing a novel pathogenic mechanism for dysferlin cardiomyopathy.
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Hypothesis-generating for dysferlin in lusitropy; leaves open relevance to human cardiomyopathy and need for targeted studies.
Wei et al. (2015) studied this question.
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