What question did this study set out to answer?

To determine whether doublecortin (DCX) expression can reliably quantify dynamic changes in adult mammalian neurogenesis under stimulatory and pathological conditions.

January 1, 2005European Journal of Neuroscience

Doublecortin expression levels in adult brain reflect neurogenesis

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Authors

SCSébastien Couillard‐DesprésParacelsus Medical University BWBeate WinnerFriedrich-Alexander-Universität Erlangen-Nürnberg SSSusanne SchaubeckUniversity of Regensburg

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Implication

Experimental study demonstrates that doublecortin expression reliably quantifies changes in adult neurogenesis, highlighting its potential for assessing human brain plasticity without in vivo...

Key Points

To determine whether doublecortin (DCX) expression can reliably quantify dynamic changes in adult mammalian neurogenesis under stimulatory and pathological conditions.
Quantified DCX-expressing cells across two models known to stimulate neurogenesis: physical activity and epileptic seizures.
Evaluated DCX expression during physiological gliogenesis, reactive gliogenesis, and regenerative axonal growth to assess marker specificity.
Quantification of DCX-positive cells accurately captured increases in adult neurogenesis induced by running and epileptic seizures.
DCX expression was absent during both physiological and reactive gliogenesis, as well as during regenerative axonal growth, confirming strict specificity for neurogenesis.

Cite This Study

Couillard‐Després et al. (2005) studied this question.

synapsesocial.com/papers/69d57425def4cefba5c22a73 https://doi.org/10.1111/j.1460-9568.2004.03813.x

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Implication

Experimental study demonstrates that doublecortin expression reliably quantifies changes in adult neurogenesis, highlighting its potential for assessing human brain plasticity without in vivo...

Doublecortin expression levels in adult brain reflect neurogenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Doublecortin expression levels in adult brain reflect neurogenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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