In patients with HFpEF, right ventricular structure and function deteriorate more progressively over time than the left ventricle, highlighting right ventricular dysfunction as a key pathophysiological feature and potential therapeutic target.
RV deterioration may identify higher-risk HFpEF patients; hypothesis-generating and should not yet change practice.
While previous attention has centred on the left ventricle in HFpEF, these data show that right ventricular structure and function deteriorate to greater extent over time when compared with changes in the left ventricle. Further study is required to evaluate whether interventions targeting modifiable risk factors identified for incident RVD, including abnormal haemodynamics, AF, coronary disease, and obesity, can prevent RVD and thus improve outcomes.
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Obokata et al. (2018) studied this question.
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