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March 30, 2021DiagnosticsOpen Access

In multivariate analysis, the cTnI pericardial fluid/serum ratio and age were independent predictors of death from myocardial infarction.

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Why the study?

Establishing a conclusive diagnosis solely from autopsy findings is difficult in unexpected deaths, and the optimal sampling site for postmortem troponin determination remains debated.

Does the postmortem cardiac Troponin I pericardial fluid/serum ratio predict the diagnosis of acute myocardial infarction in sudden cardiac death cases?

Population

175 forensic cases

Comparison

48 AMI deaths vs 127 controls

Authors

DHDiana Hernández‐RomeroMVMaría del Rocío Valverde-VázquezJRJuan Pedro Hernández del Rincón

Discussion

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Member takes

Overview

May complement inconclusive autopsies for AMI; leaves open prospective validation before any diagnostic adoption.

Structured PICO

Does the postmortem cardiac Troponin I pericardial fluid/serum ratio predict the diagnosis of acute myocardial infarction in sudden cardiac death cases?

P
Population
175 forensic cases of sudden cardiac death, divided into acute myocardial infarction (AMI) deaths (n=48, 27.4%) and a control group (n=127, 72.6%).
I
Intervention
Determination of postmortem cardiac Troponin I (cTnI) pericardial fluid/serum ratio
O
Outcome
Diagnosis of acute myocardial infarction (AMI) as the cause of sudden cardiac deathsurrogate

The postmortem cTnI pericardial fluid/serum ratio is an independent predictor of AMI and can serve as a complementary diagnostic tool in nonconclusive autopsies.

Cite This Study

Hernández‐Romero et al. (2021) studied this question.

synapsesocial.com/papers/69d575e8493d9d40f84426b6https://doi.org/10.3390/diagnostics11040614
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