Randomized, controlled trials have become the gold standard of medical knowledge. Yet their scientific and political history offers lessons about the complexity of medicine and disease and the economic and political forces shaping the production and circulation of knowledge.

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Bothwell et al. (Thu,) studied this question.

synapsesocial.com/papers/69d5760e734fad6b67f4c91a https://doi.org/https://doi.org/10.1056/nejmms1604593

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Assessing the Gold Standard — Lessons from the History of RCTs | Synapse

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Emergence of Zaire Ebola Virus Disease in Guinea2014 · 1,386 citations
2Medical Ethics and Controlled Trials1963 · 263 citations
3Uneasy Alliance — Clinical Investigators and the Pharmaceutical Industry2000 · 772 citations
4The Emergence of the Randomized Controlled Trial: Origins to 19802014 · 4 citations
5Activism, Drug Regulation, and the Politics of Therapeutic Evaluation in the AIDS Era: A Case Study of ddC and the `Surrogate Markers' Debate1997 · 114 citations