Why the study?
Anthracycline cancer therapy is complicated by severe side effects including cardiotoxicity and the development of chemoresistance.
This review provides an overview of anthracycline mechanisms, toxicity including cardiotoxicity, and strategies to overcome chemoresistance.
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Summarizes anthracycline cardiotoxicity mechanisms; extends literature but leaves open prospective validation of resistance strategies.
Mattioli et al. (2023) studied this question.
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