What question did this study set out to answer?

To compare left atrial morphology, size, and functional mechanics using strain imaging between patients with transthyretin cardiac amyloidosis and hypertrophic cardiomyopathy.

January 1, 2016Circulation JournalOpen Access

Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy　– Comparative Strain Imaging Study –

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Why the study?

How do left atrial morphology, size, and function compare between patients with transthyretin cardiac amyloidosis, primary hypertrophic cardiomyopathy, and controls?

Key Points

To compare left atrial morphology, size, and functional mechanics using strain imaging between patients with transthyretin cardiac amyloidosis and hypertrophic cardiomyopathy.
Performed comparative echocardiographic strain imaging to analyze left atrial morphology, reservoir function, and pump function across disease groups and control subjects.
Left atrial reservoir and pump functions were significantly impaired in both transthyretin cardiac amyloidosis and hypertrophic cardiomyopathy cohorts compared with controls.
Impairment of left atrial mechanics was significantly more severe in transthyretin cardiac amyloidosis than in hypertrophic cardiomyopathy, occurring independently of left atrial volume and left ventricular ejection fraction.

Structured PICO

How do left atrial morphology, size, and function compare between patients with transthyretin cardiac amyloidosis, primary hypertrophic cardiomyopathy, and controls?

Population

Patients with Transthyretin Cardiac Amyloidosis (TTR-CA) and Primary Hypertrophic Cardiomyopathy (HCM), and controls

Comparator

Controls

Outcome

Left atrial morphology, size, and function (specifically LA reservoir and pump function)surrogate

Left atrial reservoir and pump function are more severely impaired in transthyretin cardiac amyloidosis than in hypertrophic cardiomyopathy, independent of LA volume and LVEF, suggesting a more altered LA wall structure.

Implication

LA strain differences may aid TTR-CA differentiation from HCM; hypothesis-generating and should not yet change practice.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Gregorio et al. (2016) studied this question.

synapsesocial.com/papers/69d5765d62196bac97d9bb00 https://doi.org/10.1253/circj.cj-16-0364

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Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy　– Comparative Strain Imaging Study –

Key Points

Structured PICO

Implication

Discussion

Cite This Study

Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy　– Comparative Strain Imaging Study –

Key Points

Structured PICO

Implication

Discussion

Cite This Study

Keep reading

Keep reading

Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy – Comparative Strain Imaging Study –

Key Points

Structured PICO

Implication

Discussion

Cite This Study

Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy – Comparative Strain Imaging Study –

Key Points

Structured PICO

Implication

Discussion

Cite This Study

Keep reading

Keep reading

Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy　– Comparative Strain Imaging Study –

Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy　– Comparative Strain Imaging Study –