Why the study?
Does sacubitril/valsartan added to amlodipine reduce 24-h ambulatory BP and PP in Asian patients with systolic hypertension uncontrolled with amlodipine monotherapy?
Population
Asian patients with systolic hypertension uncontrolled with amlodipine monotherapy
Comparison
Sacubitril/valsartan added to amlodipine vs Amlodipine monotherapy
Authors
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Supports adding sacubitril/valsartan to amlodipine for uncontrolled hypertension; extends limited RCT evidence in Asian patients.
Does sacubitril/valsartan added to amlodipine reduce 24-h ambulatory BP and PP in Asian patients with systolic hypertension uncontrolled with amlodipine monotherapy?
The addition of sacubitril/valsartan to amlodipine effectively reduces 24-hour ambulatory blood pressure in Asian patients with uncontrolled systolic hypertension.
Wang et al. (2016) studied this question.