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February 12, 2013Circulation Cardiovascular Imaging622 citationsOpen Access

99m Tc-Pyrophosphate Scintigraphy for Differentiating Light-Chain Cardiac Amyloidosis From the Transthyretin-Related Familial and Senile Cardiac Amyloidoses

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SBSabahat BokhariACAdam CastañoTPTed Pozniakoff

Key Points

  • The study aims to evaluate the effectiveness of 99m Tc-pyrophosphate scintigraphy in differentiating light-chain cardiac amyloidosis from transthyretin-related cardiac amyloidosis.
  • Utilized 99m Tc-PYP scintigraphy for cardiac imaging
  • Focused on differentiating AL from ATTR cardiac amyloidosis
  • Identified a simple method to distinguish between AL and ATTR types of cardiac amyloidosis
  • Proposed the need for larger prospective studies to validate these findings.

Abstract

(99m)Tc-PYP cardiac imaging distinguishes AL from ATTR cardiac amyloidosis and may be a simple, widely available method for identifying subjects with ATTR cardiac amyloidosis, which should be studied in a larger prospective manner.

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Cite This Study

Bokhari et al. (2013) studied this question.

synapsesocial.com/papers/69d5768ae1904fea15e911e8https://doi.org/10.1161/circimaging.112.000132
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrocardiographic Features in Transthyretin Cardiac Amyloidosis2025 · 1 citations
  2. 299mTc-Pyrophosphate Scintigraphy: History, Evolution, and Role in Cardiac Amyloidosis2025
  3. 399mTc-Pyrophosphate Scintigraphy: History, Evolution, and Role in Cardiac Amyloidosis2025
  4. 4Diagnosis of ATTR cardiac amyloidosis by 99mTc-PYP scintigraphy: case series.2026
  5. 5[99mTc]Tc-Pyrophosphate Scintigraphy for Cardiac Amyloidosis: Evaluation of Scintigraphy Findings and Their Prognostic Value2025