Key result
99mTc-PYP scintigraphy remains essential for diagnosing ATTR-CM as detailed in a historical review.
Why the study?
The authors aimed to discuss the history and evolution of the pyrophosphate scan, which plays an important role in the diagnosis of ATTR amyloidosis amid increasing disease prevalence.
This review highlights the historical development and current diagnostic importance of 99mTc-pyrophosphate scintigraphy in identifying ATTR cardiac amyloidosis.
Reinforces 99mTc-PYP scintigraphy role in ATTR-CA diagnosis; leaves open protocol standardization and outcome validation.
Cardiac amyloidosis is an important cause of heart failure, particularly among the elderly population. It manifests as restrictive cardiomyopathy resulting from myocardial infiltration of misfolded amyloid fibrils (light chain or transthyretin), leading to heart failure with preserved ejection fraction. The two main forms of cardiac amyloidosis are amyloid light chain and transthyretin-related (ATTR). There has been a notable increase in the prevalence of cardiac amyloidosis due to advances in diagnostic methods and effective treatment for ATTR amyloidosis after the discovery of tafamidis. We aim to discuss the interesting history and evolution of the pyrophosphate scan, which plays an important role in the diagnosis of ATTR amyloidosis.
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Jamal et al. (2025) conducted a review in Cardiac amyloidosis. 99mTc-Pyrophosphate Scintigraphy was evaluated. 99mTc-Pyrophosphate Scintigraphy plays an important role in the diagnosis of transthyretin-related cardiac amyloidosis, as detailed in this historical review.
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