Why the study?
Innate immunity serves as the first line of defense against invasive pathogens and plays an important role in the pathogenetic process of avian infectious bronchitis virus infection.
Understanding the innate immune response to IBV in chickens could provide useful information for novel vaccine development and intervention programs.
May inform IBV vaccine strategies in poultry; leaves open translation of innate immune targets to validated interventions.
Avian infectious bronchitis virus (IBV) is an important gammacoronavirus. The virus is highly contagious, can infect chickens of all ages, and causes considerable economic losses in the poultry industry worldwide. In the last few decades, numerous studies have been published regarding pathogenicity, vaccination, and host immunity-virus interaction. In particular, innate immunity serves as the first line of defense against invasive pathogens and plays an important role in the pathogenetic process of IBV infection. This review focuses on fundamental aspects of host innate immune responses after IBV infection, including identification of conserved viral structures and different components of host with antiviral activity, which could provide useful information for novel vaccine development, vaccination strategies, and intervention programs.
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Zhang et al. (2021) studied this question.
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