Mononuclear phagocytes are not required for the progression of cardiac remodeling in established pressure-overload heart failure.
Mononuclear phagocytes may not drive late remodeling in established hypertrophy; hypothesis-generating for stage-specific interventions in pressure-overload HF.
Mononuclear phagocytes populations expand in a phasic manner in the heart during pressure-overload. However, they are dispensable for the progression of remodeling and failure once significant hypertrophy is evident and blood monocytosis has normalized.
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Patel et al. (2017) studied this question.
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