Mononuclear phagocytes are not required for the progression of cardiac remodeling in established pressure-overload heart failure.
Mononuclear phagocytes populations expand in a phasic manner in the heart during pressure-overload. However, they are dispensable for the progression of remodeling and failure once significant hypertrophy is evident and blood monocytosis has normalized.
Patel et al. (Thu,) studied this question.