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July 29, 2020SHILAP Revista de lepidopterología198 citationsOpen Access

Roles and molecular mechanisms of physical exercise in cancer prevention and treatment

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QWQiaoyun WangWZWenli Zhou

Key Points

  • To review the influence of physical exercise on cancer prevention and treatment, identify tailored exercise strategies for different cancer types and stages, and elucidate the underlying metabolic and immune mechanisms.
  • Synthesized published literature regarding the physiological and clinical effects of exercise on cancer development and progression.
  • Assessed evidence-based exercise modalities across varying cancer stages and detailed the molecular mechanisms governing metabolism and systemic immunity.
  • Exercise consistently enhances aerobic fitness, improves physical function, reduces fatigue, and boosts quality of life throughout cancer management.
  • Physical activity regulates key molecular pathways linked to cellular metabolism and systemic immune function, mitigating cancer progression and treatment-related complications.

Abstract

Exercise can enhance motivation to change lifestyle behaviors, improve aerobic fitness, improve physical function, control fatigue, and enhance quality of life. Studies have demonstrated the benefits to be gained from physical exercise, highlighting the importance of popularizing the concept of physical exercise for individuals and making professional exercise-treatment programs available to patients with cancer. However, the correlation between physical exercise and carcinogenesis is easily overlooked, and exercise interventions are not routinely provided to patients with cancer, especially those with advanced cancer. In this article, we present a literature review of the effects of exercise on cancer development and progression and give recent evidence for the type of exercise best suited for different types of cancer and in different disease stages. Moreover, the molecular mechanisms about regulating metabolism and systemic immune function in cancer are summarized and discussed. In conclusion, physical exercise should be considered as an important intervention for preventing and treating cancer and its complications.

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Cite This Study

Wang et al. (2020) studied this question.

synapsesocial.com/papers/69d576fac23ff40c2825e0e5https://doi.org/10.1016/j.jshs.2020.07.008
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