Case series identifies Bordetella holmesii as a cause of bacteremia in children with sickle cell disease, suggesting urgent diagnostic awareness.
Bordetella holmesii is a rare but increasingly recognized cause of invasive infection in children with sickle cell disease, often misidentified as B. pertussis due to evolving diagnostic limitations and reduced β-lactam susceptibility. We describe 2 cases of bacteremia, highlighting diagnostic challenges and emphasizing the importance of clinical recognition to guide timely, appropriate antimicrobial therapy and improve outcomes.
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Harris et al. (2026) studied this question.
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