Key result
Severe pertussis leukocytosis in young infants is linked to ~60% mortality from pulmonary hypertension-induced myocardial failure.
Why the study?
Fatal myocardial failure secondary to pulmonary hypertension in young infants with Bordetella pertussis infection and severe leukocytosis is poorly understood and lacks effective therapeutic approaches.
Population
5 young infants with Bordetella pertussis infection and severe leukocytosis
Design
Case series
Authors
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May precipitate fatal pulmonary hypertension in pertussis infants with leukocytosis; hypothesis-generating and should not yet change practice.
Case Report (n=5)
Bordetella pertussis infection in young infants can lead to fatal myocardial failure secondary to pulmonary hypertension, highlighting the need for new therapeutic approaches.
Donoso et al. (2005) conducted a case report in Bordetella pertussis infection with fatal myocardial failure secondary to pulmonary hypertension (n=5). Bordetella pertussis infection was evaluated on Early death. Among 5 young infants with Bordetella pertussis infection and severe leukocytosis, 3 died early from fatal myocardial failure secondary to pulmonary hypertension despite intensive management.
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