Microbial-enzymatic co-fermentation enhanced the beneficial effects of highland barley bran on preventing metabolic disorders and gut microbiota dysbiosis induced by high-fat diet in obese mice

Xuewei Feng; Muyu Feng; Yajun Cui; Junchao Wu; Siqi Zhang; Ting Bai; Yuhong Zhang; F. Zhong; Yang Yao; Sumei Zhou; Dianzhi Hou

doi:10.1039/d6fo00739b

January 1, 2026Food & Function

Microbial-enzymatic co-fermentation enhanced the beneficial effects of highland barley bran on preventing metabolic disorders and gut microbiota dysbiosis induced by high-fat diet in obese mice

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Key Points

The central aim is to assess how microbial-enzymatic co-fermentation of highland barley bran influences gut microbiota and metabolic health in obese mice.
Administered highland barley bran and fermented products to obese mice
Monitored metabolic markers and gut microbiota composition
Performed comparative analysis against control groups
Microbial-enzymatic co-fermentation significantly improved bioavailability of phenolic compounds
Reduced incidence of metabolic disorders in treated mice
Enhanced diversity of gut microbiota was observed with treatment

Implication

Demonstrates improved effects of highland barley bran on gut health in obese mice, suggesting novel dietary strategies for metabolic disorders.

Abstract

Highland barley bran (HBB) is rich in phenolic compounds, but they predominantly exist in bound forms, which severely affect their bioavailability and efficacy. This study aimed to investigate the effect...

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69d5f00974eaea4b11a79991 https://doi.org/10.1039/d6fo00739b

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Microbial-enzymatic co-fermentation enhanced the beneficial effects of highland barley bran on preventing metabolic disorders and gut microbiota dysbiosis induced by high-fat diet in obese mice

Key Points

Implication

Abstract

Discussion

Cite This Study

Microbial-enzymatic co-fermentation enhanced the beneficial effects of highland barley bran on preventing metabolic disorders and gut microbiota dysbiosis induced by high-fat diet in obese mice

Key Points

Implication

Abstract

Discussion

Cite This Study

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