Findings demonstrate higher tracer uptake with 18F-FDG compared to 68Ga-FAP-2286 in aggressive breast cancer, indicating diagnostic implications.
Metaplastic breast carcinoma is a rare, aggressive malignancy that most commonly exhibits a triple-negative phenotype; its clinical, pathologic, and imaging diagnosis can be challenging, and treatment outcomes and prognosis are generally poor. Here, we report the discrepant imaging findings on 18F-FDG PET/CT and 68Ga-FAP-2286 PET/CT in a 47-year-old woman with metaplastic carcinoma of the breast with mesenchymal differentiation and pulmonary and lymph node metastases: tracer uptake in both the primary lesion and metastatic sites was markedly higher on 18F-FDG PET/CT than on the corresponding 68Ga-FAP-2286 PET/CT.
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Zhang et al. (2026) studied this question.
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