Pediatric Intracranial Abscesses in a Tertiary Care Center: Antimicrobial Management, Diagnostic Yield of Molecular Testing and Radiologic Follow-Up

Roberto Privato; Federica Attaianese; Carlotta Montagnani; Agnese Tamborino; Elena Chiappini; Francesco Nieddu; Maria Moriondo; Angelo Galano; Flavio Giordano; Federico Mussa; Giuseppe Indolfi; Sandra Trapani; Luisa Galli; Elisabetta Venturini

doi:10.1097/inf.0000000000005240

April 6, 2026The Pediatric Infectious Disease Journal

Pediatric Intracranial Abscesses in a Tertiary Care Center: Antimicrobial Management, Diagnostic Yield of Molecular Testing and Radiologic Follow-Up

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Key Points

The aim is to evaluate antimicrobial management and the diagnostic value of molecular testing in pediatric intracranial abscesses.
Analyzed pediatric cases of intracranial abscesses in a tertiary care center.
Assessed the effectiveness of molecular testing for pathogen identification.
Examined radiologic follow-up findings and their prognostic implications.
Molecular testing significantly improved pathogen identification rates.
There is variability in antimicrobial treatment strategies and follow-up imaging procedures.
The prognostic importance of radiologic findings remains uncertain.

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Implication

Multidisciplinary care improves outcomes in pediatric intracranial abscesses, suggesting better strategies are needed.

Abstract

Pediatric intracranial abscesses require intensive multidisciplinary care, with marked heterogeneity in current treatment strategies. Molecular testing substantially enhances diagnostic yield and pathogen identification. Radiologic structural sequelae are common, but their prognostic significance remains unclear. Standardized pediatric protocols and well-designed prospective studies are needed to optimize antimicrobial stewardship, define which candidates may safely receive shorter intravenous courses, and harmonize follow-up imaging.

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Privato et al. (2026) studied this question.

synapsesocial.com/papers/69d5f09e74eaea4b11a7a116 https://doi.org/10.1097/inf.0000000000005240

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Pediatric Intracranial Abscesses in a Tertiary Care Center: Antimicrobial Management, Diagnostic Yield of Molecular Testing and Radiologic Follow-Up

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Pediatric Intracranial Abscesses in a Tertiary Care Center: Antimicrobial Management, Diagnostic Yield of Molecular Testing and Radiologic Follow-Up

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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