Angiocentric T-cell lymphoma in a cat

A 15-y-old, castrated male domestic shorthair cat was presented with a 3-d history of lethargy, inappetence, and significant weight loss. Clinical findings included moderate non-regenerative anemia, granular lymphocytes in a blood smear, and abdominal ultrasonographic abnormalities, including splenic mottling and lymphadenomegaly. Atypical lymphocytes that contained engulfed erythrocytes were found on cytologic evaluation of peritoneal fluid and splenic and lymph node aspirates. Despite supportive treatment, the patient rapidly declined and was euthanized. Histologically, neoplastic round cells were centered on blood vessels throughout lungs, liver, spleen, kidneys, and brain. Immunohistochemistry confirmed CD3-positive cells, and PCR revealed a clonal T-cell receptor gene, establishing a diagnosis of angiocentric T-cell lymphoma. Neoplastic infiltration of the myenteric plexus likely caused chronic intestinal pseudo-obstruction, explaining the gastrointestinal signs. Lymphoma should be considered in cases of disseminated vasculopathy.