What question did this study set out to answer?

To examine trends in survival outcomes after allogeneic transplantation for myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN).

April 8, 2026British Journal of Haematology

Trends in survival outcomes after allogeneic transplantation for MDS and MDS / MPN in a real‐world experience: A 25‐year nationwide study

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Authors

HIHidehiro ItonagaNagasaki University Hospital YMYasushi MiyazakiNagasaki University Hospital NTNoriaki TachiNational Defense Medical College

Discussion

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Implication

Nationwide analysis demonstrates improved survival outcomes in patients with myelodysplastic syndromes after transplantation, indicating progress in treatment.

Key Points

To examine trends in survival outcomes after allogeneic transplantation for myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN).
Analyzed a nationwide database of 7175 patients who received their first allo-HSCT from 1998 to 2022.
Calculated hazard ratios to assess mortality trends over time in different MDS subtypes.
Evaluated non-relapse mortality and relapse incidence across disease categories.
Overall mortality decreased over time in early and advanced MDS, chronic myelomonocytic leukaemia, and atypical chronic myeloid leukaemia.
Significant reductions in non-relapse mortality were observed, particularly in MDS patients.
No significant change in overall mortality was noted in MDS/MPN-unclassified and therapy-related myeloid neoplasms.

Cite This Study

Itonaga et al. (2026) studied this question.

synapsesocial.com/papers/69d5f0bb74eaea4b11a7a1cf https://doi.org/10.1111/bjh.70463

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Implication

Nationwide analysis demonstrates improved survival outcomes in patients with myelodysplastic syndromes after transplantation, indicating progress in treatment.

Trends in survival outcomes after allogeneic transplantation for MDS and MDS / MPN in a real‐world experience: A 25‐year nationwide study

Discussion

Member takes

Implication

Key Points

Cite This Study

Trends in survival outcomes after allogeneic transplantation for MDS and MDS / MPN in a real‐world experience: A 25‐year nationwide study

Discussion

Member takes

Implication

Key Points

Cite This Study

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