What question did this study set out to answer?

The aim is to establish Clinical and Laboratory Standards Institute (CLSI) endorsed epidemiological cutoff values (ECVs) for key Sporothrix species.

Establishment of epidemiological cutoff values for clinically relevant Sporothrix species using CLSI-broth microdilution

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Establishes epidemiological cutoff values for antifungals in Sporothrix species, implying enhanced resistance monitoring is needed.

The aim is to establish Clinical and Laboratory Standards Institute (CLSI) endorsed epidemiological cutoff values (ECVs) for key Sporothrix species.
Collected 3,504 minimum inhibitory concentration (MIC) values for six antifungal agents from 19 international laboratories.
Evaluated susceptibility according to CLSI M57 guidelines for determining ECVs.
Focused on three species: Sporothrix brasiliensis, S. schenckii, and S. globosa.
Found high ECVs for amphotericin B: 8 µg/mL for S. brasiliensis and S. globosa, and 4 µg/mL for S. schenckii.
Established itraconazole ECVs at 4 µg/mL for both S. brasiliensis and S. schenckii.
Identified ECVs for posaconazole at 4 µg/mL for all species, noted as tentative for S. globosa.
Revealed a low prevalence of non-wild-type isolates (<10%) for most species, except S. schenckii and posaconazole.

Santos et al. (2026) studied this question.

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