Single-nucleus transcriptome data of the hypothalamus in db/db and db/m mice.

Single-nucleus transcriptome data from the hypothalamus of db/db and db/m mice was analyzed, offering comprehensive insights into the etiology of diabetes and obesity. The study presents a detailed characterization of gene co-expression in the hypothalamus of db/db and db/m mice. It uncovers varied patterns of communication between different neuronal clusters in the hypothalamus, with the most notable being the altered interaction patterns between Agrp neurons and other neurons, while also shedding light on the molecular features of these changes.