[ ¹⁸ F]Fluorodeoxyglucose positron emission tomography ([ ¹⁸ F ] FDG PET) Characterizes Neurodegeneration Levels Across the α‐ Synucleinopathy Continuum

Beatrice Orso; Ignacio Roura; Pietro Mattioli; Francesco Famà; Federico Massa; Luigi Lorenzini; Andrea Brugnolo; Nicola Girtler; Mattia Losa; Stefano Raffa; Luca Sofia; Monica Roascio; Gabriele Arnulfo; Silvia Morbelli; Matteo Pardini; Dario Arnaldi

doi:10.1002/mds.70301

April 5, 2026Movement DisordersOpen Access

[ ¹⁸ F]Fluorodeoxyglucose positron emission tomography ([ ¹⁸ F ] FDG PET) Characterizes Neurodegeneration Levels Across the α‐ Synucleinopathy Continuum

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Key Points

The research aims to explore how [18F]FDG PET can identify levels of neurodegeneration along the continuum of α-synucleinopathy.
Utilized [18F]FDG PET imaging to analyze neurodegenerative patterns.
Focused on the transition from prodromal to overt α-synucleinopathy stages.
Emphasized the cognitive-predominant dementia-first pathway.
[18F]FDG PET effectively differentiated between various stages of α-synucleinopathy.
Best outcomes observed in assessing cognitive decline related to dementia.
Patterns demonstrated high efficiency in characterizing neurodegeneration.

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Implication

Research demonstrates effective FDG PET patterns in assessing neurodegeneration levels in neurodegenerative diseases, indicating cognitive decline.

Abstract

[¹⁸F]FDG PET disease-related patterns efficiently characterize neurodegeneration from prodromal to overt α-synucleinopathy, best assessing the cognitive-predominant (dementia-first) pathway.

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Cite This Study

Orso et al. (2026) studied this question.

synapsesocial.com/papers/69d5f13674eaea4b11a7ab9a https://doi.org/10.1002/mds.70301

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[ ¹⁸ F]Fluorodeoxyglucose positron emission tomography ([ ¹⁸ F ] FDG PET) Characterizes Neurodegeneration Levels Across the α‐ Synucleinopathy Continuum

Key Points

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Implication

Abstract

Discussion

Cite This Study

[ ¹⁸ F]Fluorodeoxyglucose positron emission tomography ([ ¹⁸ F ] FDG PET) Characterizes Neurodegeneration Levels Across the α‐ Synucleinopathy Continuum

Key Points

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Implication

Abstract

Discussion

Cite This Study

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