Key result
GABAergic anxiolysis acutely reduces anxiety-associated somatic symptoms via central inhibition of limbic and autonomic overactivation.
GABAergic modulation may alleviate somatic and visceral symptoms of anxiety via central neuroautonomic suppression rather than direct peripheral effects.
Central GABA modulation may relieve anxiety somatic symptoms; extends evidence for neuroautonomic suppression over peripheral mechanisms.
Anxiety-related syndromes are associated with dysregulation of central autonomic networks, leading to somatic, motor, and visceral symptom expression. GABAergic anxiolysis may acutely reduce symptom burden through central inhibition of limbic and autonomic overactivation. This may secondarily reduce motor tension, smooth muscle dysregulation, and lower urinary tract instability without implying direct reversal of intrinsic renal pathology.
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Aydin Kolcak (2026) studied this question. GABAergic anxiolysis acutely reduces anxiety-associated somatic symptoms, including motor tension and urinary instability, via central inhibition of limbic and autonomic overactivation.
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