Study demonstrates diagnostic value of p53 and Smad4 IHC in pancreatic ductal adenocarcinoma, suggesting improved accuracy for molecular testing.
Our study highlights the complementary diagnostic value of p53 and Smad4 IHC relative to molecular testing in PDAC, especially when tissue is limited, as commonly encountered in FNB specimens. The newly established Smad4 IHC classification system, which integrates an intermediate expression category into the conventional two-tier framework, demonstrates superior clinical utility and enhances predictive accuracy for SMAD4 genomic alterations.
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Zhao et al. (2026) studied this question.
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