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August 15, 2025Open Access

Supplementary Figure 2 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Gilbert Z. Murimwa N. Williams Dina Alzhanova Amir Mohammadi Jill M. Westcott Francisca Beato Ruifan Dai Luis Nivelo Francesca Rossi Henry K. Fleming Alexandra F. Tassielli Zeynep Yazgan Jason E. Toombs Jason B. Fleming Aatur D. Singhi Cecilia G. Ethun Huocong Huang Rolf A. Brekken

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Key Points

SMAD4 deficiency increases pancreatic cancer progression and alters immune response.
Key evidence shows mutant SMAD4 correlates with significant immune landscape changes in PDA.
Analysis of human pancreatic ductal adenocarcinoma revealed differences between SMAD4 WT and mutant forms.
This suggests TGFβ treatment may have different effects based on SMAD4 status, necessitating tailored therapies.

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Implication

Study demonstrates altered immune landscape in pancreatic cancer with SMAD4 deficiency, suggesting TGFβ's role in progression.

Abstract

Immune landscape of SMAD4 WT and mutant human PDA

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Cite This Study

Murimwa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1ac https://doi.org/10.1158/0008-5472.29918605

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
2Supplementary Figure 7 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
3Supplementary Figure 5 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
4Supplementary Figure 4 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
5Supplementary Figure 3 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025