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August 15, 2025Open Access

Supplementary Figure 4 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Gilbert Z. Murimwa N. Williams Dina Alzhanova Amir Mohammadi Jill M. Westcott Francisca Beato Ruifan Dai Luis Nivelo Francesca Rossi Henry K. Fleming Alexandra F. Tassielli Zeynep Yazgan Jason E. Toombs Jason B. Fleming Aatur D. Singhi Cecilia G. Ethun Huocong Huang Rolf A. Brekken

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Key Points

Loss of smad4 leads to significant changes in the transcriptome of pancreatic cancer cells, indicating alterations in gene expression.
Key evidence shows that smad4 deficiency promotes pancreatic cancer progression, adding complexity to treatment strategies.
This observational analysis reveals how tgfβ inhibition may interact with pancreatic cancer cells lacking smad4.
These findings highlight potential challenges in targeting tgfβ in pancrease-related treatments due to smad4's role.

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Implication

Loss of Smad4 alters the transcriptome in pancreatic cancer cells, suggesting increased cancer progression with TGFβ inhibition.

Abstract

Loss of Smad4 alters the transcriptome of pancreatic cancer cells

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Cite This Study

Murimwa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1a5 https://doi.org/10.1158/0008-5472.29918599

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 5 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
2Supplementary Figure 1 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
3Supplementary Figure 3 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
4Supplementary Figure 7 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
5Supplementary Figure 2 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025