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August 15, 2025Open Access

Supplementary Figure 7 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Gilbert Z. Murimwa N. Williams Dina Alzhanova Amir Mohammadi Jill M. Westcott Francisca Beato Ruifan Dai Luis Nivelo Francesca Rossi Henry K. Fleming Alexandra F. Tassielli Zeynep Yazgan Jason E. Toombs Jason B. Fleming Aatur D. Singhi Cecilia G. Ethun Huocong Huang Rolf A. Brekken

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Key Points

TGFβ inhibition reduces survival in mice with pancreatic tumors, highlighting a critical finding.
Mice bearing 6620c1 orthotopic tumors exhibited decreased survival when TGFβ was inhibited, indicating significant impact.
Assessment of tumor response to TGFβ inhibition was conducted using a specific mouse model, providing valuable insights.
These findings suggest a potential target for treatment, yet emphasize the need for further investigation in human studies.

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Implication

Inhibition of TGFβ reduces survival in mice with pancreatic tumors, suggesting a link to SMAD4 deficiency.

Abstract

Inhibition of TGFb reduces survival in mice bearing 6620c1 orthotopic tumors

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Cite This Study

Murimwa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1e5 https://doi.org/10.1158/0008-5472.29918590

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 3 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
2Supplementary Figure 1 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
3Supplementary Figure 5 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
4Supplementary Figure 4 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
5Supplementary Figure 2 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025