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August 15, 2025Open Access

Supplementary Figure 1 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Gilbert Z. Murimwa N. Williams Dina Alzhanova Amir Mohammadi Jill M. Westcott Francisca Beato Ruifan Dai Luis Nivelo Francesca Rossi Henry K. Fleming Alexandra F. Tassielli Zeynep Yazgan Jason E. Toombs Jason B. Fleming Aatur D. Singhi Cecilia G. Ethun Huocong Huang Rolf A. Brekken

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Key Points

Pancreatic cancer progression is significantly impacted by smad4 deficiency, promoting adverse outcomes.
Evidence suggests tgfβ inhibition correlates with the presence of gene family loss of heterozygosity (loh) in tumors.
Analysis highlights the role of smad mosaicism in altering cancer dynamics, further complicating treatment options.
Findings underscore the importance of understanding genetic factors in developing targeted therapies for pancreatic cancer.

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Implication

SMAD4 deficiency drives pancreatic cancer progression and influences tgfβ signaling dynamics, indicating potential treatment strategies.

Abstract

TGFb gene family LOH and SMAD mosaicism

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Cite This Study

Murimwa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd177 https://doi.org/10.1158/0008-5472.29918608

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 7 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
2Supplementary Figure 4 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
3Supplementary Figure 5 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
4Supplementary Figure 2 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
5Supplementary Figure 3 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025